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p90 RSK1 Antibody (OASE00376)

  • Catalog#: OASE00376
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400ul
$215.00
Discontinued
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Conjugation Options

OASE00376-FITC Conjugated

OASE00376-HRP Conjugated

OASE00376-Biotin Conjugated

Gene Symbol:
RPS6KA1
NCBI Gene Id:
6195
Official Gene Full Name:
ribosomal protein S6 kinase, 90kDa, polypeptide 1
Swissprot Id:
Q15418
Protein Accession #:
NP_002944.2
Replacement Item:
This antibody may replace item sc-130870 from Santa Cruz Biotechnology.
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Rabbit immunoglobulin
Application:
WB, IP, ELISA
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express RPS6KA1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express RPS6KA1.
Immunogen:
Human p90 RSK1 C-terminal peptide, conjugated to KLH
Reconstitution and Storage:
Store at -20C. Shipping in Blue Ice or 4C.
Concentration:
250ug/mL
Datasheets/Manuals:
Printable datasheet for OASE00376
Dilution:
1ug/mL (WB)
Additional Information:
Background Info: Detects a ~90kDa protein corresponding to the molecular mass of p90 RSK1 on SDS PAGE immunoblots.
:::
Scientific Background: The p90 ribosomal S6 kinase (Rsk) family comprises four mammalian serine/threonine kinases (Rsk1–4). In the past, S6K1 and S6K2 were thought to be the predominant operating S6 kinases, however RSK 1 and 2 have been shown to phosphorylate S6 in response to the ERK pathway, or otherwise known as the extra cellular signal-regulated kinases pathway. RSK 1 in particular is very multifunctional as it participates in nuclear signaling, regulates nuclear factors, regulates several transcription factors like c-Fos, and interacts with the transcriptional coactivator CREB-binding protein. As a result, RSK1 seems to have an important role in cellular growth control and proliferation. (1-5).
:::
Certificate of Analysis: 0.25mg/ml was sufficient for detection of 7 in lysates prepared from mouse brain, spleen and intestine.
Target Reference:
1. Roux, P. (2007). UCSD-Nature Molecule Pages. 2. Fro¨din, M. and Gammeltoft, S. (1999) Mol. Cell.
Endocrinol. 151: 65-77.
3. Merienne, K. et al. (1998) J. Med. Genet. 35: 890-894.
4. De Cesare, D. et al. (1998) Proc. Natl. Acad.
Sci. 95: 12202-12207.
5. Joel, P. B. et al. (1998) Mol. Cell. Biol. 18:
1978-1984.
Storage Buffer:
TBS, 50% glycerol, 0.09% sodium azide

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