Size:400ul
$215.00
Discontinued
SKU
OASE00375
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Conjugation Options

OASE00375-FITC Conjugated

OASE00375-HRP Conjugated

OASE00375-Biotin Conjugated

p70 S6K Antibody (OASE00375)

Catalog#: OASE00375
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This product is Genway GWB-0X0006
More Information
Predicted Species Reactivity Human, Mouse, Rat, Bovine
Clonality Polyclonal
Host Rabbit
Application WB, IP
Additional Information Background Info: Detects a ~70kDa protein corresponding to the molecular mass of p70 S6K on SDS PAGE immunoblots.
:: Scientific Background: Ribosomal S6 (S6K) belongs to the AGC family of Serine/Threonine protein kinases. There are two forms of S6K, alpha and beta, which have cytoplasmic and nuclear variants derived from alternative splicing (1). The activity of S6K is regulated by phosphorylation/ dephosphorylation events in cellular responses to various extracellular stimuli. Its activity has also been shown to be dependent on nutrient availability (3-6). The mechanism of activation of S6K is a multi-step process which is achieved by phosphorylating the 40S ribosomal protein S6, which then upregulates the translation of mRNA transcripts containing an oligopryimidine tract at the 5' transcriptional start site (3-6). Recently, a highly homologous ribosomal S6 kinase, termed S6K2, was identified. It has 70% amino acid identity in the overall sequence with S6K1, and highly conserved potential phosphorylation sites of S6K1. However, the N- and C-terminal domains of S6K2 are quite different (2). As a result, S6K is a key player in the regulation of cell size, growth and glucose homeostasis.
:: Certificate of Analysis: 0.25mg/mL was sufficient for detection of in lysates prepared from mouse muscle and mouse brain.
Reconstitution and Storage Store at -20C. Shipping in Blue Ice or 4C.
Replacement Item This antibody may replace item sc-39209 from Santa Cruz Biotechnology.
Immunogen Human p70 S6K c-terminal peptide –KLH conjugates
Purification Rabbit immunoglobulin
Concentration 250ug/mL
Datasheets/Manuals Printable datasheet for OASE00375
Dilution 1ug/mL (WB)
Target Reference 1. Gout, I. et al. (1998). J Biol Chem. 273 (46):30061-30064. 2. Val'Ovka, TI. et al. (2000). Ukr Biokhim Zh.
72(3):31-7.
3. Kawasome, H. et al. (1998) Proc. Natl. Acad.
Sci. 95
4. Montagne, J. et al. 1999) Science 285
5. Shima, H. et al. (1998) EMBO J 17: 6649-
6659.
6. Lee-Fruman, K. et al. (1999) Oncogene 18:
5108- 5114.
Storage Buffer TBS, 50% glycerol, 0.09% sodium azide
Gene Symbol RPS6KB2
Official Gene Full Name ribosomal protein S6 kinase, 70kDa, polypeptide 2
NCBI Gene Id 6199
Swissprot Id Q9UBS0
Protein Accession # NP_003943.2
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express RPS6KB2.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express RPS6KB2.
  1. What is the species homology for "p70 S6K Antibody (OASE00375)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat, Bovine".

  2. How long will it take to receive "p70 S6K Antibody (OASE00375)"?

    This item is available "Domestic: within 3-5 days delivery | International: 3-5 days".

  3. What buffer format is "p70 S6K Antibody (OASE00375)" provided in?

    This item is provided in "".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "p70 S6K Antibody (OASE00375)"?

    This target may also be called "" in publications.

  5. What is the shipping cost for "p70 S6K Antibody (OASE00375)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "p70 S6K Antibody (OASE00375)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "p70 S6K Antibody (OASE00375)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "p70 S6K Antibody (OASE00375)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "RPS6KB2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "RPS6KB2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "RPS6KB2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "RPS6KB2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "RPS6KB2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "RPS6KB2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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