P63 Antibody (OASL01221)

Catalog No: OASL01221

Size:50ul

Immunohistochemical analysis of paraffin-embedded Breast. 1, Antibody was diluted at 1:200 (4C, overnight) . 2, Citric acid, pH6.0 was used for antigen retrieval.

Immunohistochemical analysis of paraffin-embedded Breast. 1, Antibody was diluted at 1:200 (4C, overnight) . 2, Citric acid, pH6.0 was used for antigen retrieval.

Product Info

• Product Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Monoclonal
• Isotype: IgG1, Kappa
• Host: Mouse
• Application: IHC-P
• Additional Information: Background: tumor protein p63(TP63) Homo sapiens this gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrim).
  Function: cofactor: binds 1 zinc ion per subunit, disease: defects in TP63 are a cause of cervical, colon, head and neck, lung and ovarian cancers, disease: defects in TP63 are a cause of ectodermal dysplasia Rapp-Hodgkin type (EDRH) [MIM: 129400]; also called Rapp-Hodgkin syndrome or anhidrotic ectodermal dysplasia with cleft lip/palate. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDRH is characterized by the combination of anhidrotic ectodermal dysplasia, cleft lip, and cleft palate. The clinical syndrome is comprised of a characteristic facies (narrow nose and small mouth), wiry, slow-growing, and uncombable hair, sparse eyelashes and eyebrows, obstructed lacrimal puncta/epiphora, bilateral stenosis of external auditory canals, microsomia, hypodontia, cone-shaped incisors, enamel hypoplasia, dystrophic nails.
  Location: Function: cofactor: binds 1 zinc ion per subunit, disease: defects in TP63 are a cause of cervical, colon, head and neck, lung and ovarian cancers, disease: defects in TP63 are a cause of ectodermal dysplasia Rapp-Hodgkin type (EDRH) [MIM: 129400]; also called Rapp-Hodgkin syndrome or anhidrotic ectodermal dysplasia with cleft lip/palate. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDRH is characterized by the combination of anhidrotic ectodermal dysplasia, cleft lip, and cleft palate. The clinical syndrome is comprised of a characteristic facies (narrow nose and small mouth), wiry, slow-growing, and uncombable hair, sparse eyelashes and eyebrows, obstructed lacrimal puncta/epiphora, bilateral stenosis of external auditory canals, microsomia, hypodontia, cone-shaped incisors, enamel hypoplasia, dystrophic nails.
  Expression: Keratinocyte, Lymph, Placenta, Prostate, Skeletal muscle.
• Reconstitution and Storage: Store at -20C for one year. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human p63
• Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
• Concentration: 1 mg/ml
• Specificity: This antibody detects endogenous levels of human p63
• Application Info: IHC-P 1:200

Target Info

• Gene Symbol: TP63
• Alias Symbols: AIS, KET, LMS, NBP, RHS, p40, p51, p63, EEC3, OFC8, p73H, p73L, SHFM4, TP53L, TP73L, p53CP, TP53CP, B(p51A), B(p51B)
• NCBI Gene Id: 8626
• Protein Name: Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)
• Uniprot ID: Q9H3D4