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Catalog No: OAPA00081 (Formerly GWB-D3B8EB)
Size:2UG
Price: $75.00
SKU
OAPA00081
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
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p53 Antibody (OAPA00081)

Datasheets/ManualsPrintable datasheet for anti-p53 antibody - OAPA00081
Product Info
Product Formatp53 is supplied in 10mM Tris HCl, pH 8, 100mM NaCl and 50% glycerol. Physical appearance: Sterile Filtered clear solution.
ClonalityMonoclonal
HostE. Coli
::Product Type: Antibody Recombinant.
::Product Introduction: Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome.
Product Description: p53 or TP53 is a cell cycle related transcription factor that promotes transcription of genes that induce cell cycle arrest or apoptosis in response to DNA damage or other cell stresses.This tumour suppressor gene is mutated in about half of all human cancers.Recombinant Anti p53 produced in E.Coli is a non-glycosylated, polypeptide chain containing a hexahistidine tag and having a molecular weight of 37 kDa.p53 is purified by proprietary chromatographic techniques.
Reconstitution and StorageStore at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. Please avoid freeze thaw cycles.
PurityGreater than 95.0% as determined by SDS-PAGE.
Gene Symbolp53
Alias SymbolsP53, BCC7, LFS1, BMFS5, TRP53
NCBI Gene Id7157
Protein NameCellular tumor antigen p53
Description of TargetRecombinant Anti p53 scFv
Uniprot IDP04637
Protein Accession #NP_000537.3
Protein Size (# AA)Recombinant
  1. What is the species homology for "p53 Antibody (OAPA00081)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "".

  2. How long will it take to receive "p53 Antibody (OAPA00081)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "p53 Antibody (OAPA00081)" provided in?

    This item is provided in "p53 is supplied in 10mM Tris HCl, pH 8, 100mM NaCl and 50% glycerol. Physical appearance: Sterile Filtered clear solution.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "p53 Antibody (OAPA00081)"?

    This target may also be called "P53, BCC7, LFS1, BMFS5, TRP53" in publications.

  5. What is the shipping cost for "p53 Antibody (OAPA00081)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "p53 Antibody (OAPA00081)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "p53 Antibody (OAPA00081)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "p53 Antibody (OAPA00081)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "P53"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "P53"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "P53"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "P53"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "P53"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "P53"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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