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p53 Antibody (Methyl-Lys372) (OADC00189)

Catalog#: OADC00189
Domestic: within 1 week delivery | International: 1 week
More Information
Predicted Species ReactivityHuman
Product FormatLiquid. Provided in PBS containing 0.05% azide and 0.05% ProClin 300.
ApplicationWB, CHIP
Reconstitution and StorageStore at -20C. Avoid repeated freeze/thaw cycles.
Replacement ItemThis antibody may replace item sc-126 from Santa Cruz Biotechnology.
PurificationProtein G purified
Concentration2 mg/mL
Datasheets/ManualsPrintable datasheet for anti-TP53 (OADC00189) antibody
Preservative0.05% Sodium Azide and 0.05% ProClin 300.
Target Post-Translational ModificationMethyl-Lys372
SpecificityPolyclonal antibody raised in rabbit against human p53 (tumor protein p53), methylated at K372, using a KLH-conjugated synthetic peptide.
Application InfoWestern Blotting: 1:200
Gene SymbolTP53
Official Gene Full Nametumor protein p53
Alias SymbolsP53, BCC7, LFS1, TRP53
NCBI Gene Id7157;
Protein Namecellular tumor antigen p53
Description of TargetThis gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).
Swissprot IdP04637
Protein Accession #NP_000537.3
Nucleotide Accession #NM_000546.5
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express TP53.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express TP53.
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