P4HB Recombinant Protein (OPCD06079)

Catalog No: OPCD06079

P4HB Recombinant Protein (OPCD06079) using SDS-PAGE

P4HB Recombinant Protein (OPCD06079) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Rat|Rattus norvegicus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Asp269-Asp507
  Subcellular Location: Endoplasmic reticulum lumen. Melanosome. Cell membrane; Peripheral membrane prote
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: P4hb
• Gene Full Name: prolyl 4-hydroxylase subunit beta
• Alias Symbols: cellular thyroid hormone-binding protein;PDI;PDIR;Prolyl 4-hydroxylase subunit beta;prolyl 4-hydroxylase, beta polypeptide;Protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide);protein disulfide-isomerase.
• NCBI Gene Id: 25506
• Protein Name: Protein disulfide-isomerase
• Description of Target: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
• Uniprot ID: P04785
• Protein Accession #: NP_037130.2
• Nucleotide Accession #: NM_012998.2
• Protein Size (# AA): Asp269~Asp507
• Molecular Weight: 57kDa