Catalog No: OPCD06079
Price: $0.00
SKU
OPCD06079
Availability: Domestic: within 1-2 weeks delivery | International: within 1-2 weeks delivery
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Datasheets/Manuals | Printable datasheet for P4HB Recombinant Protein (OPCD06079) |
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Predicted Species Reactivity | Rat|Rattus norvegicus |
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Product Format | Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
Host | E.coli |
Conjugation | Unconjugated |
Application | Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot |
Additional Information | Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) |
:: | Residues: Asp269-Asp507 |
:: | Subcellular Location: Endoplasmic reticulum lumen. Melanosome. Cell membrane; Peripheral membrane prote |
Reconstitution and Storage | 2°C to 8°C|-80°C |
Concentration | 200 ug/mL (prior to lyoph) |
Purity | > 95% |
Source | E.coli |
Tag | N-terminal His and GST Tag |
Gene Symbol | P4hb |
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Gene Full Name | prolyl 4-hydroxylase subunit beta |
Alias Symbols | cellular thyroid hormone-binding protein;PDI;PDIR;Prolyl 4-hydroxylase subunit beta;prolyl 4-hydroxylase, beta polypeptide;Protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide);protein disulfide-isomerase. |
NCBI Gene Id | 25506 |
Protein Name | Protein disulfide-isomerase |
Description of Target | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. |
Uniprot ID | P04785 |
Protein Accession # | NP_037130.2 |
Nucleotide Accession # | NM_012998.2 |
Protein Size (# AA) | Asp269~Asp507 |
Molecular Weight | 57kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
-
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