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P4HB antibody - C-terminal region (ARP48151_P050)

100 ul
$289.00
In Stock

Conjugation Options

ARP48151_P050-FITC Conjugated

ARP48151_P050-HRP Conjugated

ARP48151_P050-Biotin Conjugated

Gene Symbol:
P4HB
NCBI Gene Id:
5034
Official Gene Full Name:
Prolyl 4-hydroxylase, beta polypeptide
Protein Name:
Protein disulfide-isomerase
Swissprot Id:
P07237
Protein Accession #:
NP_000909
Nucleotide Accession #:
NM_000918
Alias Symbols:
DSI, ERBA2L, GIT, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB, P4Hbeta
Replacement Item:
This antibody may replace item sc-111237 from Santa Cruz Biotechnology.
Description of Target:
P4HB is the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Size (# AA):
508
Molecular Weight:
55kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB, IHC
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express P4HB.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express P4HB.
Immunogen:
The immunogen is a synthetic peptide directed towards the C terminal region of human P4HB
Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
Complete computational species homology data:
Anti-P4HB (ARP48151_P050)
Peptide Sequence:
Synthetic peptide located within the following region: DRTVIDYNGERTLDGFKKFLESGGQDGAGDDDDLEDLEEAEEPDMEEDDD
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
P4HB; UBC; AGO2; MDM2; SUZ12; RNF2; EZH2; BMI1; rev; ACAA2; PLIN3; UBA2; USP5; TPD52L2; PSMD9; PFDN2; CLNS1A; TCEAL4; P3H1; UBQLN2; PABPC1; CALU; PARK2; HNRNPD; EGFR; UBD; BAG3; CXCR4; env; UBL4A; CSNK2A2; ATF2; GRDX; TMED9; GANAB; CCT4; CCT7; PDIA6; PDIA
Blocking Peptide:
For anti-P4HB (ARP48151_P050) antibody is Catalog # AAP48151 (Previous Catalog # AAPP28662)
Datasheets/Manuals:
Printable datasheet for anti-P4HB (ARP48151_P050) antibody
Sample Type Confirmation:

P4HB is strongly supported by BioGPS gene expression data to be expressed in HepG2

Target Reference:
Ewing,R.M., Mol. Syst. Biol. 3, 89 (2007)

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