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Catalog No: OASE00074 (Formerly GWB-CE9E00)
Size:25ug
Price: $169.00
SKU
OASE00074
Availability: Discontinued
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Datasheets/ManualsPrintable datasheet for OASE00074
Product Info
Predicted Species ReactivityHuman, Mouse, Rat
ClonalityMonoclonal
Clone9F12
IsotypeIgG1
HostMouse
ConjugationUnconjugated
ApplicationWB, IHC, IP, ELISA, AM
Additional InformationBackground Info: Detects a ~38kDa protein corresponding to the molecular mass of p38alpha MAPK on SDS PAGE immunoblots.
::Scientific Background: The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, proteinserine/
threonine kinases which signal transduction
pathways that control intracellular events including
acute responses to hormones and major developmental
changes in organisms (1). This super family consists of
stress activated protein kinases (SAPKs); extracellular
signal-regulated kinases (ERKs); and p38 kinases, each of
which forms a separate pathway (2). The kinase members
that populate each pathway are sequentially activated by
phosphorylation. Upon activation, p38 MAPK/SAPK2alpha
translocates into the nucleus where it phosphorylates
one or more nuclear substrates, effecting transcriptional
changes and other cellular processes involved in cell
growth, division, differentiation, inflammation, and
death (3). Specifically p38 always acts as a pro-apoptotic
factor with its activation leading to the release of
cytochrome c from mitochondria and cleavage of caspase
3 and its downstream effector, PARP (4). p38 MAPK is
activated by a variety of chemical stress inducers
including hydrogen peroxide, heavy metals, anisomycin,
sodium salicylate, LPS, and biological stress signals such
as tumor necrosis factor, interleukin-1, ionizing and UV
irradiation, hyperosmotic stress and chemotherapeutic
drugs (5).
As a result, p38 alpha has been widely validated as a
target for inflammatory disease including rheumatoid
arthritis, COPD and psoriasis (6) and has also been
implicated in cancer, CNS and diabetes (7).
::Certificate of Analysis: Detects ~38kDa protein corresponding to p38alpha MAPK when loaded with 6ng of purified p38alpha by chemiluminescent immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Reconstitution and StorageStore at -20C. Shipping with Blue Ice or 4C.
ImmunogenFull length recombinant protein expressed in E.coli cells
PurificationProtein G Purified
Concentration1 mg/ml
SpecificityDetects ~38kDa.
DilutionWB (1:1000), IHC (1:1000); optimal dilutions for assays should be determined by the user.
Storage BufferPBS, 50% glycerol, 0.09% sodium azide
Reference1. Pearson, G. et al (2001). Endocrine Reviews 22 (2):153-183.
2. Fan, Y. et al (2007) Mol. Cells 23 (1): 30-38.
3. Han, J. et al. (1994) Science 265: 808-811.
4. Van, L. A., et al. (2004) Faseb J. 18: 1946−1948.
5. Deng et al. (2003) Cell. 115: 61-70.
6. Salojin KV, et al. (2006) J Immunol. 176 (3):1899-
907.
7. Medicherla S. et al. (2006). J Pharmacol Exp Ther.
318(1): 99-107.
DescriptionThe MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, proteinserine/ threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms (1). This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway (2). The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2α translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death (3). Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP (4). p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs (5). As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis (6) and has also been implicated in cancer, CNS and diabetes (7).
Gene Symbolp38 MAPK
Gene Full Namemitogen-activated protein kinase 14
Alias SymbolsCSAID Binding protein 1, CSBP1, CSBP2, EXIP, MAP kinase MXI2, MAPkinase p38alpha, MAPK14, p38 ALPHA, p38 MAP kinase, p38 mitogen activated protein kinase, RK, SAPK 2A, Stress activated protein kinase 2A
NCBI Gene Id1432
Uniprot IDQ16539
Protein Accession #NP_001306.1
  1. What is the species homology for "p38 alpha (MAP Kinase) Antibody (OASE00074)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "p38 alpha (MAP Kinase) Antibody (OASE00074)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "p38 alpha (MAP Kinase) Antibody (OASE00074)" provided in?

    This item is provided in "".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "p38 alpha (MAP Kinase) Antibody (OASE00074)"?

    This target may also be called "CSAID Binding protein 1, CSBP1, CSBP2, EXIP, MAP kinase MXI2, MAPkinase p38alpha, MAPK14, p38 ALPHA, p38 MAP kinase, p38 mitogen activated protein kinase, RK, SAPK 2A, Stress activated protein kinase 2A" in publications.

  5. What is the shipping cost for "p38 alpha (MAP Kinase) Antibody (OASE00074)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "p38 alpha (MAP Kinase) Antibody (OASE00074)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "p38 alpha (MAP Kinase) Antibody (OASE00074)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "p38 alpha (MAP Kinase) Antibody (OASE00074)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "p38 MAPK"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "p38 MAPK"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "p38 MAPK"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "p38 MAPK"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "p38 MAPK"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "p38 MAPK"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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