p29 ING4 CONTROL PEPTIDE (OERA00068)

Catalog No: OERA00068

Size:50UG

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Liquid (sterile filtered)
• Conjugation: Unconjugated
• Reconstitution and Storage: 2°C to 8°C|-20°C
• Concentration: 1 mg/ml

Target Info

• Gene Symbol: ING4
• Gene Full Name: inhibitor of growth family member 4
• Alias Symbols: brain my036 protein;candidate tumor suppressor p33 ING1 homolog;inhibitor of growth protein 4;my036;p29ING4.
• NCBI Gene Id: 51147
• Protein Name: Inhibitor of growth protein 4
• Description of Target: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).
• Uniprot ID: Q9UNL4