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Catalog No: OASE00083-Biotin
Size:100ug
Price: $349.00
SKU
OASE00083-Biotin
Availability: Domestic: within 3-5 days delivery | International: 3-5 days
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p23 Antibody : Biotin (OASE00083-Biotin)

Datasheets/ManualsPrintable datasheet for OASE00083-Biotin
Product Info
Predicted Species ReactivityHuman, Mouse, Rabbit, Chicken, Guinea pig, S. cerevisiae
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer.
ClonalityMonoclonal
CloneJJ6
IsotypeIgG1
HostMouse
ConjugationBiotin
ApplicationWB, IP, ELISA
Additional InformationBackground Info: Detects ~23kDa.
::Scientific Background: p23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the
hsp90 chaperoning system (1). Studies have revealed that
p23 is a small protein (18 to 25 kDa) with a simple
structure (2, 3). p23 does not have any structural
homology with any other known proteins (1). p23 was
first discovered as a part of the Hsp90-progesterone
receptor complex along with hsp70, p54 and p50 (1). p23
is a phosphor-protein, which is highly acidic and has an
aspartic acid-rich c-terminal domain (1). Numerous
studies have found p23 to be associated with other client
proteins like Fes tyrosine kinase (4), the heme regulated
kinase HRI (5), hsf1 transcription factor (4), aryl
hydrocarbon receptor (4), telomerase (6), and
Hepadnavirus reverse transcriptase (7). In spite of
several years of study, the exact functional significance
of p23 is still not clear (8). p23 is thought to be involved
in the adenosine triphosphate–mediated hsp90 binding of
client proteins (8). Since many hsp90 client proteins are
involved in oncogenic survival signaling, a recent study
has concluded p23 to be a promising target in leukemic
apoptosis (9). Hsp90 and its co-chaperone p23 are
certainly among the emerging anti-tumor targets in
oncology.
::Certificate of Analysis: 0.5ug/mL was sufficient for detection of p23 in 20ug of heat shocked cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Reconstitution and StorageAll conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
ImmunogenRecombinant Human full length p23 protein
PurificationProtein G Purified
Concentration1 mg/ml
Dilution1:2000 (WB)
Storage BufferPBS, 50% glycerol
Reference1. Johnson J.L., Beito T. G., Krco C.J. & Toft D.O. (1994) Mol Cell Biol 14: 1956-63.
2. Weikl T., Abelmann K. & Buchner J. (1999) J Mol Biol
293: 685-91.
3. Weaver A.J., Sullivan W.P., Felts S.J., Owen B.A. &
Toft, D.O. (2000) J Biol Chem 275: 23045-52.
4. Nair S.C., et al. (1996) Cell Stress Chaperones 1: 237-
50.
5. Xu Z., et al. (1997) Eur J Biochem 246, 461-70.
6. Holt S.E., et al. (1999) Genes Dev 13: 817-26.
7. Hu J., Toft D., Anselmo D. & Wang X. (2002) J Virol
76: 269-79.
8. Felts, S.J. & Toft D.O. (2003) Cell Stress Chaperones
8: 108-13.
9. Gausdal G., Gjertsen B.T., Fladmark K.E., Demol H.,
Vandekerckhove J. & Doskeland S.O. (2004)
Leukemia.
Gene SymbolPTGES3
Gene Full Nameprostaglandin E synthase 3 (cytosolic)
Alias SymbolsP23, TEBP, cPGES
NCBI Gene Id10728
Uniprot IDQ15185
Protein Accession #NP_006592.3
  1. What is the species homology for "p23 Antibody : Biotin (OASE00083-Biotin)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rabbit, Chicken, Guinea pig, S. cerevisiae".

  2. How long will it take to receive "p23 Antibody : Biotin (OASE00083-Biotin)"?

    This item is available "Domestic: within 3-5 days delivery | International: 3-5 days".

  3. What buffer format is "p23 Antibody : Biotin (OASE00083-Biotin)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "p23 Antibody : Biotin (OASE00083-Biotin)"?

    This target may also be called "P23, TEBP, cPGES" in publications.

  5. What is the shipping cost for "p23 Antibody : Biotin (OASE00083-Biotin)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "p23 Antibody : Biotin (OASE00083-Biotin)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "p23 Antibody : Biotin (OASE00083-Biotin)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "p23 Antibody : Biotin (OASE00083-Biotin)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "PTGES3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "PTGES3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "PTGES3"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "PTGES3"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "PTGES3"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "PTGES3"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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