Catalog No: OPCA00517
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OTUB1 Recombinant Protein (Human) (OPCA00517)

Datasheets/ManualsPrintable datasheet for OTUB1 Recombinant Protein (Human) (OPCA00517) (OPCA00517)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatLiquid or Lyophilized powder
Additional Information Tag information : GST tag
Reconstitution and Storage-20°C or -80°C
PurityGreater than 90% as determined by SDS-PAGE.
Storage BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Protein Range2-201 aa
TagN-terminal GST-tagged
ReferenceHuman chromosome 11 DNA sequence and analysis including novel gene identification.Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.Nature 440:497-500(2006)
Gene SymbolOTUB1
Gene Full NameOTU deubiquitinase, ubiquitin aldehyde binding 1
Alias Symbolsdeubiquitinating enzyme OTUB1;HSPC263;OTB1;OTU domain, ubiquitin aldehyde binding 1;OTU domain-containing ubiquitin aldehyde-binding protein 1;OTU1;otubain-1;OTU-domain Ubal-binding 1;ubiquitin thioesterase OTUB1;ubiquitin-specific protease otubain 1;ubiquitin-specific-processing protease OTUB1.
NCBI Gene Id55611
Protein NameUbiquitin thioesterase OTUB1
Description of TargetHydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin.
Uniprot IDQ96FW1
Protein Size (# AA)Recombinant
Molecular Weight50.1 kDa
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