Aviva Systems Biology will be closed in observance of Good Friday 3/29/2024. If you are in need of any assistance please email info@avivasysbio.com

Catalog No: ARP39525_P050
Price: $0.00
SKU
ARP39525_P050
Availability: Domestic: within 1-2 days delivery | International: 1-2 days
Bulk
Order
Aviva's
Satisfaction
Guarantee
Contact Us:
Shipping Info:
  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
  • Contact us for international orders.
Datasheets/ManualsPrintable datasheet for anti-OPTN (ARP39525_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Rat, Cow, Dog, Guinea Pig, Horse
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB, IHC
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human OPTN
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 86%; Dog: 83%; Guinea Pig: 79%; Horse: 86%; Human: 100%; Rat: 79%
Peptide SequenceSynthetic peptide located within the following region: SHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTEN
Concentration0.5 mg/ml
Blocking PeptideFor anti-OPTN (ARP39525_P050) antibody is Catalog # AAP39525 (Previous Catalog # AAPP21540)
ReferenceMorton,S., (2008) FEBS Lett. 582 (6), 997-1002
Gene SymbolOPTN
Gene Full NameOptineurin
Alias SymbolsNRP, FIP2, HIP7, HYPL, ALS12, GLC1E, TFIIIA-INTP
NCBI Gene Id10133
Protein NameOptineurin
Description of TargetOPTN is the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins.This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Uniprot IDQ96CV9
Protein Accession #NP_001008214
Nucleotide Accession #NM_001008213
Protein Size (# AA)577
Molecular Weight66kDa
Protein InteractionsRAB10; TNIP1; OPTN; DAZAP2; CDC23; UBC; PARK2; ZNF670; ZNF329; TBC1D15; ZNF398; CCDC53; MAP1LC3A; TBC1D17; HACE1; RAB25; RAB11B; SQSTM1; RAB11A; Rab8a; Tfrc; BRE; FAM178A; UQCRQ; GNAS; RAB12; EPS15; RAB14; MAP1LC3B; PIAS4; RNF11; RIPK1; TNFRSF1A; TNF; HTT
  1. What is the species homology for "OPTN Antibody - N-terminal region (ARP39525_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Rat, Cow, Dog, Guinea Pig, Horse".

  2. How long will it take to receive "OPTN Antibody - N-terminal region (ARP39525_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "OPTN Antibody - N-terminal region (ARP39525_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "OPTN Antibody - N-terminal region (ARP39525_P050)"?

    This target may also be called "NRP, FIP2, HIP7, HYPL, ALS12, GLC1E, TFIIIA-INTP" in publications.

  5. What is the shipping cost for "OPTN Antibody - N-terminal region (ARP39525_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "OPTN Antibody - N-terminal region (ARP39525_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "OPTN Antibody - N-terminal region (ARP39525_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "66kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "OPTN Antibody - N-terminal region (ARP39525_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "OPTN"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "OPTN"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "OPTN"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "OPTN"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "OPTN"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "OPTN"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

Write Your Own Review
You're reviewing:OPTN Antibody - N-terminal region (ARP39525_P050)
Your Rating
We found other products you might like!