OPRK1 Antibody (OAAF00752)

Catalog No: OAAF00752 (Formerly GWB-ASC156)

Size:100 ug

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using KOR-1 Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Mouse|Rat
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from mouse KOR-1.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: KOR-1 antibody detects endogenous levels of total KOR-1 protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: IHC: 1:50~1:100; ELISA: 1:5000
• Reference: Wen S Sheng, J. Pharmacol. Exp. Ther., May 2007; 10.1124/jpet.107.121988.
  DB Joseph, J. Pharmacol. Exp. Ther., Mar 1995; 272: 970.
  Tracey A. Ignatowski, J. Pharmacol. Exp. Ther., Jan 1998; 284: 298.

Target Info

• Gene Symbol: Oprk1
• Gene Full Name: opioid receptor, kappa 1
• Alias Symbols: kappa-type opioid receptor;KOR;KOR-1;K-OR-1;MSL-1;Op;opioid receptor, kappa 2;Oprk2;R2;R21.
• NCBI Gene Id: 18387
• Protein Name: Kappa-type opioid receptor
• Description of Target: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
• Uniprot ID: P33534
• Protein Accession #: NP_000903.2
• Molecular Weight: 42 kDa