OLR1 Recombinant Protein (OPCD04987)

Catalog No: OPCD04987

OLR1 Recombinant Protein (OPCD04987) using SDS-PAGE

OLR1 Recombinant Protein (OPCD04987) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Rat|Rattus norvegicus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Thr51-Ser314
  Subcellular Location: Cell membrane; Secreted. Single-pass type II membrane prote
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Olr1
• Gene Full Name: oxidized low density lipoprotein receptor 1
• Alias Symbols: lectin-like oxidized LDL receptor 1;lectin-like oxidized low-density lipoprotein receptor;Lectin-like oxidized low-density lipoprotein receptor-1;lectin-like oxLDL receptor 1;lectin-type oxidized LDL receptor 1;LOX-1;Oldlr1;Oldr1;oxidised low density lipoprotein (lectin-like) receptor 1;oxidized low density lipoprotein (lectin-like) receptor 1;oxidized low-density lipoprotein receptor 1;ox-LDL receptor 1.
• NCBI Gene Id: 140914
• Protein Name: Oxidized low-density lipoprotein receptor 1
• Description of Target: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
• Uniprot ID: O70156
• Protein Accession #: NP_579840.2
• Nucleotide Accession #: NM_133306.2
• Protein Size (# AA): Thr51~Ser314
• Molecular Weight: 34.63kDa