Catalog No: OPCD04984
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OPCD04984
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Datasheets/ManualsPrintable datasheet for OLR1 Recombinant Protein (OPCD04984)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
Subcellular Location: Cell membrane; Secreted. Single-pass type II membrane protein.
::Residues: Arg60-Pro312
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolOlr1
Gene Full Nameoxidized low density lipoprotein (lectin-like) receptor 1
Alias Symbolslectin-like oxidized LDL receptor 1;lectin-like oxLDL receptor 1;lectin-type oxidized LDL receptor 1;LOX;LOX-1;oxidised low density lipoprotein (lectin-like) receptor 1;oxidized low-density lipoprotein receptor 1;ox-LDL receptor 1;Sca;Scare1;SR;SR-EI.
NCBI Gene Id108078
Protein NameOxidized low-density lipoprotein receptor 1
Description of TargetReceptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity).
Uniprot IDQ9EQ09
Protein Accession #NP_619589.2
Nucleotide Accession #NM_138648.2
Protein Size (# AA)Arg180~Pro312
Molecular Weight33kDa
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