Catalog No: OPCD04984
Price: $0.00
SKU
OPCD04984
Availability: Domestic: within 1-2 weeks delivery | International: within 1-2 weeks delivery
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Datasheets/Manuals | Printable datasheet for OLR1 Recombinant Protein (OPCD04984) |
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Predicted Species Reactivity | Mouse|Mus musculus |
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Product Format | Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
Host | E.coli |
Conjugation | Unconjugated |
Application | Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot |
Additional Information | Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) Subcellular Location: Cell membrane; Secreted. Single-pass type II membrane protein. |
:: | Residues: Arg60-Pro312 |
Reconstitution and Storage | 2°C to 8°C|-80°C |
Concentration | 200 ug/mL (prior to lyoph) |
Purity | > 95% |
Source | E.coli |
Tag | N-terminal His Tag |
Gene Symbol | Olr1 |
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Gene Full Name | oxidized low density lipoprotein (lectin-like) receptor 1 |
Alias Symbols | lectin-like oxidized LDL receptor 1;lectin-like oxLDL receptor 1;lectin-type oxidized LDL receptor 1;LOX;LOX-1;oxidised low density lipoprotein (lectin-like) receptor 1;oxidized low-density lipoprotein receptor 1;ox-LDL receptor 1;Sca;Scare1;SR;SR-EI. |
NCBI Gene Id | 108078 |
Protein Name | Oxidized low-density lipoprotein receptor 1 |
Description of Target | Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity). |
Uniprot ID | Q9EQ09 |
Protein Accession # | NP_619589.2 |
Nucleotide Accession # | NM_138648.2 |
Protein Size (# AA) | Arg180~Pro312 |
Molecular Weight | 33kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
-
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