OGR1/GPR68 Cell Lysate (OCEG01208)

Catalog No: OCEG01208

Size:100ul

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. 10% glycerol, 0.063 M Tris-HCl (pH 6.8), 2% SDS and 0.002% bromophenol blue, 5% 2-mercaptoethanol
• Application: WB
• Reconstitution and Storage: Shipped at ambient temperature, freeze upon arrival. Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles. Products are stable for one year from purchase when stored properly.
• Concentration: 0.5 mg/ml
• Application Info: For use as a positive control with GPR68 polyclonal antibody (Cat. No. OAEG00956) for Western blot analysis.
• Reference: Xu, Y., et al. 'Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.' Nature Cell Biol. 2000: 2, 261-267

Target Info

• Description of Target: OGR1 (originally identified as GPR68) is a high-affinity receptor for sphingosylphosphorylcholine (SPC). SPC is a member of a class of bioactive lipids which regulate cellular functions. These functions include cell proliferation and growth inhibition, smooth muscle contration and wound healing. SPC also stimulated signalling pathways that induce tyrosine phosphorylation, activate MAP kinases and protein kinase C, modify ion channel activity and increase intracellular Ca2+ concentration. OGR1 is expressed in placenta, lung, liver, spleen, testis, small intestine and peripheral blood leukocytes. It is not found in thymus, ovary, colon, skeletal muscle, kidney or pancreas.