OASL Antibody - C-terminal region (OAAB16566)

Catalog No: OAAB16566

Size:400ul

The anti-OASL C-term Antibody (Cat.# OAAB16566) is used in Western blot to detect OASL in HL60 lysate.

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB, IHC, ELISA
• Additional Information: Cellular Location: Isoform p56: Nucleus, nucleolus. Cytoplasm.
  Tissue Location: Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.
• Reconstitution and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This OASL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 484-514 amino acids from the C-terminal region of human OASL.
• Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Concentration: 2 mg/ml
• Application Info: WB: 1:1000
  IHC-P: 1:50~100

Target Info

• Gene Symbol: OASL
• Alias Symbols: OASL1, OASLd, TRIP14, TRIP-14, p59OASL, p59 OASL, p59-OASL
• NCBI Gene Id: 8638
• Protein Name: 2'-5'-oligoadenylate synthase-like protein
• Description of Target: 2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted 514-amino acid human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.
• Uniprot ID: Q15646
• Protein Accession #: NP_003724.1
• Molecular Weight: 59 kDa