OAS3 Antibody (OACA10739)

Catalog No: OACA10739

Immunofluorescent analysis of A549 cells at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunohistochemistry of paraffin-embedded human brain tissue at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue at dilution of 1:100

Immunohistochemistry of paraffin-embedded human brain tissue at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue at dilution of 1:100

Immunofluorescent analysis of A549 cells at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human 2\'-5\'-oligoadenylate synthase 3 protein (424-565AA)
• Purification: Protein G Purified
• Preservative: 0.03% Proclin 300
• Formulation: 50% Glycerol, 0.01M PBS, pH 7.4
• Purity: >95%

Target Info

• Gene Symbol: OAS3
• Gene Full Name: 2'-5'-oligoadenylate synthetase 3
• Alias Symbols: (2-5')oligo(A) synthase 3;(2-5')oligo(A) synthetase 3;2-5A synthase 3;2-5A synthetase 3;2'-5'-oligoadenylate synthase 3;2'-5'-oligoadenylate synthetase 3, 100kDa;2'-5'oligoadenylate synthetase p100;p100;p100 OAS;p100OAS.
• NCBI Gene Id: 4940
• Protein Name: 2'-5'-oligoadenylate synthase 3
• Description of Target: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
• Uniprot ID: Q9Y6K5
• Protein Accession #: NP_006178
• Nucleotide Accession #: NM_006187