OAS1A Recombinant Protein (OPCD05873)

Catalog No: OPCD05873

OAS1A Recombinant Protein (OPCD05873) using SDS-PAGE

OAS1A Recombinant Protein (OPCD05873) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Rat|Rattus norvegicus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ala139-Leu358
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 90%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Oas1a
• Gene Full Name: 2'-5' oligoadenylate synthetase 1A
• Alias Symbols: (2-5')oligo(A) synthase 1;(2-5')oligo(A) synthase 1A;(2-5')oligo(A) synthetase 1;2',5'-oligoadenylate synthetase 1, 40/46kDa;25 oligoadenylate synthetase;2'-5' oligoadenylate synthetase 1G;2-5A synthase 1;2-5A synthase 1A;2-5A synthetase 1;2'-5'-oligoadenylate synthase 1;2'-5'-oligoadenylate synthase 1A;2'-5'-oligoadenylate synthetase 1;Oas1;Oas1g.
• NCBI Gene Id: 192281
• Protein Name: 2'-5'-oligoadenylate synthase 1A
• Description of Target: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.
• Uniprot ID: Q05961
• Protein Accession #: NP_620268.1
• Nucleotide Accession #: NM_138913.1
• Protein Size (# AA): Ala139~Leu358
• Molecular Weight: 33kDa