OAS1 Recombinant Protein (OPCD05874)

Catalog No: OPCD05874

OAS1 Recombinant Protein (OPCD05874) using SDS-PAGE

OAS1 Recombinant Protein (OPCD05874) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ser74-Pro165
  Subcellular Location: Cytoplasm. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Secreted
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: OAS1
• Gene Full Name: 2'-5'-oligoadenylate synthetase 1
• Alias Symbols: (2-5')oligo(A) synthase 1;2',5'-oligo A synthetase 1;2-5A synthase 1;2-5A synthetase 1;2'-5'-oligoadenylate synthase 1;2'-5'-oligoadenylate synthetase 1, 40/46kDa;2'-5'-oligoisoadenylate synthetase 1;E16 (2'-5') oligo A synthetase;E18/E16;IFI-4;OIAS;OIASI;p46/p42 OAS.
• NCBI Gene Id: 4938
• Protein Name: 2'-5'-oligoadenylate synthase 1
• Description of Target: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:34581622). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:34581622). Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
• Uniprot ID: P00973
• Protein Accession #: NP_001027581.1
• Nucleotide Accession #: NM_001032409.2
• Protein Size (# AA): Ser74~Pro165
• Molecular Weight: 11kDa