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OAS1 antibody - middle region (ARP51359_P050)

100 ul
$319.00
In Stock

Conjugation Options

ARP51359_P050-FITC Conjugated

ARP51359_P050-HRP Conjugated

ARP51359_P050-Biotin Conjugated

Gene Symbol:
OAS1
NCBI Gene Id:
4938
Official Gene Full Name:
2'-5'-oligoadenylate synthetase 1, 40/46kDa
Protein Name:
2'-5'-oligoadenylate synthase 1
Swissprot Id:
P00973-3
Protein Accession #:
NP_001027581
Nucleotide Accession #:
NM_001032409
Alias Symbols:
IFI-4, OIAS, OIASI
Replacement Item:
This antibody may replace item sc-100639 from Santa Cruz Biotechnology.
Description of Target:
This protein is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication.This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.
Protein Size (# AA):
414
Molecular Weight:
47kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express OAS1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express OAS1.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human OAS1
Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Predicted Homology Based on Immunogen Sequence:
Cow: 93%; Dog: 93%; Guinea Pig: 87%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 86%; Rat: 93%
Complete computational species homology data:
Anti-OAS1 (ARP51359_P050)
Peptide Sequence:
Synthetic peptide located within the following region: RRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDG
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
EXOC5; TRIM27; ACTN1; PRMT6; WBSCR22; RPL30; HCVgp1;
Blocking Peptide:
For anti-OAS1 (ARP51359_P050) antibody is Catalog # AAP51359 (Previous Catalog # AAPS23611)
Datasheets/Manuals:
Printable datasheet for anti-OAS1 (ARP51359_P050) antibody
Application Info:
IHC - Paraffin ~~ 5 ug/ml
Western blot ~~1 ug/ml
Target Reference:
Phosri,C., Mycol. Res. 111 (PT 3), 275-286 (2007)
Publications:

Zhu, W. et al. RIG-I-like receptors mediate innate antiviral response in mouse testis. Mol. Endocrinol. 27, 1455-67 (2013). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat 23820901

Yu, L. et al. Pattern recognition receptor-initiated innate antiviral response in mouse adipose cells. Immunol. Cell Biol. 92, 105-15 (2014). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat 24165978

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