Catalog No: ARP39251_P050
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ARP39251_P050
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Datasheets/ManualsPrintable datasheet for anti-NUP98 (ARP39251_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationIF, WB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human NUP98
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 91%; Zebrafish: 85%
Peptide SequenceSynthetic peptide located within the following region: AFGTSAFGSSNNTGGLFGNSQTKPGGLFGTSSFSQPATSTSTGFGFGTST
Concentration0.5 mg/ml
Blocking PeptideFor anti-NUP98 (ARP39251_P050) antibody is Catalog # AAP39251 (Previous Catalog # AAPY00861)
Other Applications Image 1 DataImmunofluorescence --
Sample Type: HeLa cells
Dilution: 2ug/mL
ReferencePan,Q., (2008) Oncogene 27 (24), 3414-3423
Gene SymbolNUP98
Gene Full NameNucleoporin 98kDa
Alias SymbolsADIR2, NUP96, NUP196, Nup98-96
NCBI Gene Id4928
Protein NameNuclear pore complex protein Nup98-Nup96
Description of TargetThe nuclear pore complex (NPC) is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Uniprot IDP52948-5
Protein Accession #NP_057404
Nucleotide Accession #NM_016320
Protein Size (# AA)1800
Molecular Weight196kDa
Protein InteractionsUBC; SUMO2; SUMO3; CDC37; EED; CDC73; PAF1; ARFGEF2; FBXO6; NXF1; HDAC11; HDAC8; LMNA; HNRNPUL1; CSNK2A1; ECT2; NUP107; RAE1; SUMO1; NUMA1; rev; SIRT7; RAPGEF3; CTNNB1; NUP88; NUP159; NUP82; Nup98; Nup214; Nup188; tat; HDAC1; CREBBP; PTTG1; APC; NPM1; USP
  1. What is the species homology for "NUP98 Antibody - N-terminal region (ARP39251_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish".

  2. How long will it take to receive "NUP98 Antibody - N-terminal region (ARP39251_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "NUP98 Antibody - N-terminal region (ARP39251_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "NUP98 Antibody - N-terminal region (ARP39251_P050)"?

    This target may also be called "ADIR2, NUP96, NUP196, Nup98-96" in publications.

  5. What is the shipping cost for "NUP98 Antibody - N-terminal region (ARP39251_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "NUP98 Antibody - N-terminal region (ARP39251_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "NUP98 Antibody - N-terminal region (ARP39251_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "196kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "NUP98 Antibody - N-terminal region (ARP39251_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "NUP98"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "NUP98"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "NUP98"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "NUP98"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "NUP98"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "NUP98"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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