Catalog No: OPCD05842
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OPCD05842
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Datasheets/ManualsPrintable datasheet for NUMB Recombinant Protein (OPCD05842)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Leu376-Phe482
::Subcellular Location: Membrane; Peripheral membrane prote
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolNUMB
Gene Full NameNUMB endocytic adaptor protein
Alias Symbolsc14_5527;C14orf41;h-Numb;numb homolog;protein numb homolog;Protein S171;S171.
NCBI Gene Id8650
Protein NameProtein numb homolog
Description of TargetPlays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
Uniprot IDP49757
Protein Accession #NP_001005743.1
Nucleotide Accession #NM_001005743.1
Protein Size (# AA)Leu376~Phe482
Molecular Weight33kDa
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