NUMB Antibody (Phospho-Ser276) (OABF01217)

Catalog No: OABF01217

Size:100UL

Formalin-fixed and paraffin embedded mouse embryo labeled with Anti-Phospho-Numb (Ser276) Polyclonal Antibody, Unconjugated (OABF01217) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Product Info

• Predicted Species Reactivity: Bovine|Chicken|Dog|Horse|Human|Mouse|Porcine|Rabbit|Rat|Sheep
• Product Format: Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot
• Additional Information: Subcellular location: Cell membrane
  Modification: Phosphorylation (Ser276)
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic phosphopeptide derived from human Numb around the phosphorylation site of Ser276
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: WB: 1:100 - 1000
  IHC-P: : 1:100 - 500

Target Info

• Gene Symbol: NUMB
• Gene Full Name: NUMB endocytic adaptor protein
• Alias Symbols: c14_5527;C14orf41;h-Numb;numb homolog;protein numb homolog;Protein S171;S171.
• NCBI Gene Id: 8650
• Protein Name: Protein numb homolog
• Description of Target: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
• Uniprot ID: P49757