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Catalog No: OPCD05835
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OPCD05835
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NUAK1 Recombinant Protein (OPCD05835)

Datasheets/ManualsPrintable datasheet for NUAK1 Recombinant Protein (OPCD05835)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Lys404-Leu651
::Subcellular Location: Nucleus, Cytoplasm
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His and GST Tag
Gene SymbolNuak1
Gene Full NameNUAK family, SNF1-like kinase, 1
Alias SymbolsAMPK-related protein kinase 5;AU014801;AW494241;B230104P22Rik;NUAK family SNF1-like kinase 1;omphalocele kinase 1;Omphk1;ZNUAK family, SNF1-like kinase, 1.
NCBI Gene Id77976
Protein NameNUAK family SNF1-like kinase 1
Description of TargetSerine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair.
Uniprot IDQ641K5
Protein Accession #NP_001004363.1
Nucleotide Accession #NM_001004363.1
Protein Size (# AA)Lys404~Leu651
Molecular Weight57kDa
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