NT5E Antibody (OAEC04528)

Catalog No: OAEC04528

Size:100 ug/100 ul

Immunohistochemical analysis of paraffin-embedded human lung cancer (A), cholangiocarcinorna (B), lymph node (C) and esophagus (D) tissues using NT5E mouse mAb with DAB staining.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Ascitic fluid containing 0.03% sodium azide
• Clonality: Monoclonal
• Clone: 1D7
• Isotype: IgG1
• Host: Mouse
• Application: IHC
• Reconstitution and Storage: Store at 4C, for long term storage, store at -20C.
• Immunogen: Purified recombinant fragment of NT5E expres sed in EColi.
• Concentration: 1 mg/ml
• Application Info: IHC: 1/200 - 1/1000
  ELISA: 1/10000
  

Target Info

• Gene Symbol: NT5E
• Gene Full Name: 5'-nucleotidase, ecto (CD73)
• Alias Symbols: NT, eN, NT5, NTE, eNT, CD73, E5NT, CALJA
• NCBI Gene Id: 4907
• Description of Target: 5'-nucleotidase, ecto (NT5E), also known as CD73 (Cluster of Differentiation 73).Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the convers ion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzym e consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzym e is used as a marker of lym phocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exis t in the cytoplasm and lys osomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.
• Uniprot ID: P21589
• Molecular Weight: 70 kDa