NSD2 Antibody - N-terminal region (ARP34429_T100)

Catalog No: ARP34429_T100

WB Suggested Anti-USF1 Antibody Titration: 1.25ug/ml
ELISA Titer: 1:312500
Positive Control: Jurkat cell lysateWHSC1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human USF1
• Purification: Protein A purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: DPTSVAIASIQSAATFPDPNVKYVFRTENGGQVMYRVIQVSEGQLDGQTE
• Concentration: 1.0 mg/ml
• Blocking Peptide: For anti-NSD2 (ARP34429_T100) antibody is Catalog # AAP34429 (Previous Catalog # AAPY00331)
• Sample Type Confirmation:

  WHSC1 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

• Reference: Shoulders,C.C. et al., (2004) Nat. Genet. 36 (4), 322-323

Target Info

• Gene Symbol: NSD2
• Gene Full Name: nuclear receptor binding SET domain protein 2
• Alias Symbols: WHS, TRX5, KMT3F, KMT3G, MMSET, WHSC1, REIIBP
• NCBI Gene Id: 7468
• Protein Name: histone-lysine N-methyltransferase NSD2
• Description of Target: This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.
• Uniprot ID: P22415
• Protein Accession #: NP_009053
• Nucleotide Accession #: NM_007122
• Protein Size (# AA): 310
• Molecular Weight: 34kDa
• Protein Interactions: HIST1H3A; HIST3H3; HDAC1; TRIM28; UBC; SF3A1; HNRNPR; MPHOSPH10; RAD50; SART3; NUP93; GTF3C4; NOLC1; DDX21; BAZ1B; DDX18; KHSRP; RRP1; SMARCA5; SMC1A; RBM10; XRCC5; VIM; EZR; TOP2B; TOP1; TMPO; SMARCA4; SFPQ; RPN1; RBBP4; RANGAP1; PTBP1; PRKDC; PLRG1; PKP