NRL Antibody - N-terminal region (OASG05150)

Catalog No: OASG05150

Size:100 uL

Western Blot using 293

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB
  Function: Transcription factor which regulates the expression of several rod-specific genes, including RHO and PDE6B.
  Tissue Specificity: Neural retina
  Cellular Localization: Nucleus.
• Reconstitution and Storage: Store at -20°C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the N-terminal region of human Nrl. Location: 10-90aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Disumoylated at Lys-20. Sumoylation modulates the transcriptional activity of NRL on RHO and NR2E3 promoters, and is required for normal rod differentiation (By similarity).
• Specificity: Nrl Polyclonal Antibody detects endogenous levels of Nrl protein.
• Application Info: WB: 1:500~2000
  ELISA: 1:10000

Target Info

• Gene Symbol: NRL
• Gene Full Name: neural retina leucine zipper
• Alias Symbols: RP27, D14S46E, NRL-MAF
• NCBI Gene Id: 4901; 18185;
• Description of Target: This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases.
• Uniprot ID: P54845, P54846
• Molecular Weight: 25 kDa