NRG2 Antibody - C-terminal region (OAAB16560)

Catalog No: OAAB16560

Size:400ul

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Product Info

• Predicted Species Reactivity: Human, Rat
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: IHC
• Additional Information: Precautions: NRG2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor
  Cellular Location: Pro-neuregulin-2, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein (By similarity). Note=Does not seem to be active (By similarity)
  Tissue Location: Restricted to the cerebellum in the adult.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This NRG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 358-389 amino acids from the C-terminal region of human NRG2.
• Predicted Homology Based on Immunogen Sequence: Human; Rat
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: WB: 1:1000
  IHC-P: 1:50~100

Target Info

• Gene Symbol: NRG2
• Alias Symbols: DON1, HRG2, NTAK
• NCBI Gene Id: 9542
• Protein Name: Pro-neuregulin-2, membrane-bound isoform
• Description of Target: Purified Rabbit Polyclonal Antibody (Pab)
• Uniprot ID: O14511
• Protein Accession #: NP_001171864.1
• Molecular Weight: 91679 Da