NR3C1 Recombinant Protein (OPCD05785)

Catalog No: OPCD05785

Product Info

• Predicted Species Reactivity: Rat|Rattus norvegicus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Ctrl (+), SDS-PAGE, WB
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ser106-Thr211
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: Nr3c1
• Gene Full Name: nuclear receptor subfamily 3, group C, member 1
• Alias Symbols: Gcr;glucocorticoid receptor;GR;Grl;Nuclear receptor subfamily 3 group C member 1.
• NCBI Gene Id: 24413
• Protein Name: Glucocorticoid receptor
• Description of Target: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:12917342). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity).
• Uniprot ID: P06536
• Protein Accession #: NP_036708.2
• Nucleotide Accession #: NM_012576.2
• Protein Size (# AA): Ser106~Thr211
• Molecular Weight: 49.7kDa