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NR3C1 Antibody (OADC00056)

50ug
$319.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Liquid. Provided in PBS containing 0.05% azide and 0.1% BSA; purified by ammonium sulphate precipitation followed by dialysis.
Clonality:
Monoclonal
Isotype:
IgG2b kappa
Host:
Mouse
Conjugation:
Unconjugated
Application:
CHIP, WB, GS, IHC, FC, IP
Reconstitution and Storage:
Store at -20C. Avoid repeated freeze/thaw cycles.
Replacement Item:
This antibody may replace item sc-12763 from Santa Cruz Biotechnology.
Purification:
Protein A/G purified
Predicted Homology Based on Immunogen Sequence:
Rat
Concentration:
1 mg/mL
Datasheets/Manuals:
Printable datasheet for anti-NR3C1 (OADC00056) antibody
Preservative:
0.05% Sodium Azide
Specificity:
Mouse monoclonal antibody raised against POLR2A
Application Info:
CHIP: 5 ug/CHIP
ELISA: 0.5 ug/ml
Western Blotting: 1 ug/ml
Gel Supershift 5 ug/ml
Immunochemistry 2.5 ug/ml
Flow Cytometry: 0.5 ug/ml
Immunoprecipitation: 5 ug per IP
Gene Symbol:
NR3C1
Official Gene Full Name:
nuclear receptor subfamily 3 group C member 1
Alias Symbols:
GR, GCR, GRL, GCCR, GCRST
NCBI Gene Id:
2908;
Protein Name:
glucocorticoid receptor
Description of Target:
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
Swissprot Id:
P04150
Protein Accession #:
NP_000167.1
Nucleotide Accession #:
NM_000176.2
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express NR3C1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express NR3C1.

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