NR2E3 Antibody - middle region (OAAB10504)

Catalog No: OAAB10504

Size:400ul

NR2E3 Antibody (Center) (Cat. #OAAB10504) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the NR2E3 antibody detected the NR2E3 protein (arrow).

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB
  Function: Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit Enhances rhodopsin expression. Represses M- and S-cone opsin expression.
  Cellular Location: Nucleus.
  Tissue Location: Eye specific; found solely in the outer nuclear layer of the adult neurosensory retina, where the nuclei of cone and rod photoreceptors reside.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This NR2E3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-198 amino acids from the Central region of human NR2E3.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Predicted Homology Based on Immunogen Sequence: Bovine
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: WB: 1:1000
• Publications:

  Differential dimerization of variants linked to enhanced S-cone sensitivity syndrome (ESCS) located in the NR2E3 ligand-binding domain. Hum Mutat. 36, 599-610 (2015). 25703721

• Description:
  View product citations for NR2E3 Antibody - middle region (OAAB10504) on CiteAb

Target Info

• Gene Symbol: NR2E3
• Alias Symbols: PNR, RNR, rd7, ESCS, RP37
• NCBI Gene Id: 10002
• Protein Name: Photoreceptor-specific nuclear receptor
• Description of Target: This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Uniprot ID: Q9Y5X4
• Protein Accession #: NP_055064.1
• Molecular Weight: 45 kDa