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Catalog No: P100813_P050
Price: $0.00
SKU
P100813_P050
Availability: Domestic: within 1-2 days delivery | International: 1-2 days
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Datasheets/ManualsPrintable datasheet for anti-NR2C1 (P100813_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human NR2C1
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 80%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 86%; Pig: 93%; Rabbit: 100%; Rat: 93%
Peptide SequenceSynthetic peptide located within the following region: ELFTLGLAQCWQVMNVATILATFVNCLHNSLQQDKMSTERRKLLMEHIFK
Concentration0.5 mg/ml
Blocking PeptideFor anti-NR2C1 (P100813_P050) antibody is Catalog # AAP31157 (Previous Catalog # AAPP01896)
Sample Type Confirmation

NR2C1 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

ReferenceLin,Y.L., (2006) Biochem. Biophys. Res. Commun. 350 (2), 430-436
Description
Gene SymbolNR2C1
Gene Full NameNuclear receptor subfamily 2, group C, member 1
Alias SymbolsTR2
NCBI Gene Id7181
Protein NameNuclear receptor subfamily 2 group C member 1
Description of TargetThe nuclear orphan receptors NR2C1 represses transcription and binds DNA as a homodimer. NR2C1 binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. NR2C1 may function as a negative modulator to suppress androgen receptor function in prostate cancer. NR2C1 may exert an important repressor in regulating ER activity in mammary glands. The nuclear orphan receptors TR2 (NR2C1) and TR4 form a heterodimer that binds to the epsilon and gamma globin promoter DR1 sites This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.
Uniprot IDQ15625
Protein Accession #NP_003288
Nucleotide Accession #NM_003297
Protein Size (# AA)603
Molecular Weight67kDa
Protein InteractionsPSPC1; MBD3; SIN3A; RCOR1; KDM1A; POLD3; TRIM28; RBM39; MTA2; MTA1; HDAC3; NR2C2; SMARCA4; SFPQ; RBBP7; RBBP4; NONO; HDAC2; HDAC1; HCFC1; DNMT1; CHD4; NUDT3; UBC; PML; HDAC4; NRIP1; AR; ESR1;
  1. What is the species homology for "NR2C1 Antibody - middle region (P100813_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit".

  2. How long will it take to receive "NR2C1 Antibody - middle region (P100813_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "NR2C1 Antibody - middle region (P100813_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "NR2C1 Antibody - middle region (P100813_P050)"?

    This target may also be called "TR2" in publications.

  5. What is the shipping cost for "NR2C1 Antibody - middle region (P100813_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "NR2C1 Antibody - middle region (P100813_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "NR2C1 Antibody - middle region (P100813_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "67kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "NR2C1 Antibody - middle region (P100813_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "NR2C1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "NR2C1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "NR2C1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "NR2C1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "NR2C1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "NR2C1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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