NR1I2 Recombinant Protein (OPCD06546)

Catalog No: OPCD06546

NR1I2 Recombinant Protein (OPCD06546) using SDS-PAGE

NR1I2 Recombinant Protein (OPCD06546) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Tyr205-Gly390
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: Nr1i2
• Gene Full Name: nuclear receptor subfamily 1, group I, member 2
• Alias Symbols: mP;mPXR;nuclear receptor subfamily 1 group I member 2;orphan nuclear receptor PXR;P;Pregnane X receptor;PXR;PXR.1;PXR.2;PXR1;S;SXR.
• NCBI Gene Id: 18171
• Protein Name: Nuclear receptor subfamily 1 group I member 2
• Description of Target: Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity). Activated by naturally occurring steroids such as pregnenolone and progesterone, the cholesterol metabolite 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol, synthetic glucocorticoids and antiglucocorticoids and 16-alpha-carbonitrile (PCN).
• Uniprot ID: O54915
• Protein Accession #: NP_001091874.1
• Nucleotide Accession #: NM_001098404.1
• Protein Size (# AA): Tyr205~Gly390
• Molecular Weight: 51kDa