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Datasheets/Manuals | Printable datasheet for NR1I2 Antibody (OACA07325) (OACA07325) |
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Predicted Species Reactivity | Human |
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Product Format | Liquid |
Clonality | Polyclonal |
Isotype | IgG |
Host | Rabbit |
Conjugation | Unconjugated |
Application | Enzyme-linked immunosorbent assay|Immunohistochemistry |
Reconstitution and Storage | -20°C or -80°C |
Immunogen | Recombinant Human Nuclear receptor subfamily 1 group I member 2 protein (175-434AA) |
Purification | Affinity Purified |
Preservative | 0.02% sodium azide |
Formulation | PBS with, 50% glycerol, pH7.3. |
Reference | [1]"Eleven novel single nucleotide polymorphisms in the NR1I2 (PXR) gene, four of which induce non-synonymous amino acid alterations."Koyano S., Kurose K., Ozawa S., Saeki M., Nakajima Y., Hasegawa R., Komamura K., Ueno K., Kamakura S., Nakajima T., Saito H., Kimura H., Goto Y., Saitoh O., Katoh M., Ohnuma T., Kawai M., Sugai K. Sawada J.Drug Metab. Pharmacokinet. 17:561-565(2001). [2]"Structural basis of human pregnane X receptor activation by the hops constituent colupulone."Teotico D.G., Bischof J.J., Peng L., Kliewer S.A., Redinbo M.R. Mol. Pharmacol. 74:1512-1520(2007). [3]"Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism."Xue Y., Chao E., Zuercher W.J., Willson T.M., Collins J.L., Redinbo M.R.Bioorg. Med. Chem. 15:2156-2166(2006). |
Gene Symbol | NR1I2 |
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Gene Full Name | nuclear receptor subfamily 1 group I member 2 |
Alias Symbols | BXR;nuclear receptor subfamily 1 group I member 2;ONR1;orphan nuclear receptor PAR1;orphan nuclear receptor PXR;PAR;PAR1;PAR2;PARq;pregnane X nuclear receptor variant 2;pregnane X receptor;PRR;PXR;SAR;steroid and xenobiotic receptor;SXR. |
NCBI Gene Id | 8856 |
Protein Name | Nuclear receptor subfamily 1 group I member 2 |
Description of Target | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. |
Uniprot ID | O75469 |
Protein Accession # | NP_003880 |
Nucleotide Accession # | NM_003889 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "NR1I2 Antibody (OACA07325)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "NR1I2 Antibody (OACA07325)"?
This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".
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What buffer format is "NR1I2 Antibody (OACA07325)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "NR1I2 Antibody (OACA07325)"?
This target may also be called "BXR;nuclear receptor subfamily 1 group I member 2;ONR1;orphan nuclear receptor PAR1;orphan nuclear receptor PXR;PAR;PAR1;PAR2;PARq;pregnane X nuclear receptor variant 2;pregnane X receptor;PRR;PXR;SAR;steroid and xenobiotic receptor;SXR." in publications.
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What is the shipping cost for "NR1I2 Antibody (OACA07325)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "NR1I2 Antibody (OACA07325)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "NR1I2 Antibody (OACA07325)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "NR1I2 Antibody (OACA07325)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "NR1I2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "NR1I2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "NR1I2"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "NR1I2"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "NR1I2"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "NR1I2"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.