Catalog No: ARP39738_T100
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ARP39738_T100
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NR1I2 Antibody - N-terminal region (ARP39738_T100)

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Datasheets/ManualsPrintable datasheet for anti-NR1I2 (ARP39738_T100) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Horse
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human NR1I2
PurificationProtein A purified
Predicted Homology Based on Immunogen SequenceHorse: 85%; Human: 100%
Peptide SequenceSynthetic peptide located within the following region: MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATG
Concentration1.0 mg/ml
Blocking PeptideFor anti-NR1I2 (ARP39738_T100) antibody is Catalog # AAP39738 (Previous Catalog # AAPP21763)
ReferenceDring,M.M., (2006) Gastroenterology 130 (2), 341-348
Gene SymbolNR1I2
Gene Full NameNuclear receptor subfamily 1, group I, member 2
Alias SymbolsBXR, PAR, PRR, PXR, SAR, SXR, ONR1, PAR1, PAR2, PARq
NCBI Gene Id8856
Protein NameNuclear receptor subfamily 1 group I member 2
Description of TargetNR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. NR1I2 contains a zinc finger domain.NR1I2 is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain.The gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. The gene product contains a zinc finger domain. Three alternatively spliced transcripts that encode different isoforms have been described, one of which encodes two products through the use of alternative translation initiation codons. Additional transcript variants derived from alternative promoter usage, alternative splicing, and/or alternative polyadenylation exist, but they have not been fully described.
Uniprot IDO75469
Protein Accession #NP_003880
Nucleotide Accession #NM_003889
Protein Size (# AA)434
Molecular Weight50kDa
Protein InteractionsNCOA1; RPS6KB1; UBC; RBBP7; DDB1; UBR5; DYRK2; NCOR2; SDF4; NCOA3; TFAP2C; MAPK7; NFATC4; HSP90AA1; FGR; ATP6AP1; RXRA; RBCK1; NCOA2; SUMO1; SUMO2; SUMO3; NCOA6; SRC; RXRG; RXRB; CHMP1A; NUCB2; ACTN2; PPARGC1A; EIF3I; TADA3; NCOR1; PRMT1; NR1I2; PSMC5; PO
  1. What is the species homology for "NR1I2 Antibody - N-terminal region (ARP39738_T100)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Horse".

  2. How long will it take to receive "NR1I2 Antibody - N-terminal region (ARP39738_T100)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "NR1I2 Antibody - N-terminal region (ARP39738_T100)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "NR1I2 Antibody - N-terminal region (ARP39738_T100)"?

    This target may also be called "BXR, PAR, PRR, PXR, SAR, SXR, ONR1, PAR1, PAR2, PARq" in publications.

  5. What is the shipping cost for "NR1I2 Antibody - N-terminal region (ARP39738_T100)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "NR1I2 Antibody - N-terminal region (ARP39738_T100)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "NR1I2 Antibody - N-terminal region (ARP39738_T100)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "50kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "NR1I2 Antibody - N-terminal region (ARP39738_T100)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "NR1I2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "NR1I2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "NR1I2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "NR1I2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "NR1I2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "NR1I2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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