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NR1H4 antibody - middle region (ARP45626_P050)

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100 ul
$319.00
In Stock
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Conjugation Options

ARP45626_P050-FITC Conjugated

ARP45626_P050-HRP Conjugated

ARP45626_P050-Biotin Conjugated

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Gene Symbol:
NR1H4
NCBI Gene Id:
9971
Official Gene Full Name:
Nuclear receptor subfamily 1, group H, member 4
Protein Name:
Farnesoid X receptor EMBL BAH02290.1
Swissprot Id:
B6ZGS9
Protein Accession #:
NP_005114
Nucleotide Accession #:
NM_005123
Alias Symbols:
BAR, FXR, HRR-1, HRR1, MGC163445, RIP14
Description of Target:
NR1H4 is the receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. NR1H4 represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two d
Protein Size (# AA):
472
Molecular Weight:
54kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express NR1H4.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express NR1H4.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human NR1H4
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 93%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 93%; Rat: 93%
Complete computational species homology data:
Anti-NR1H4 (ARP45626_P050)
Peptide Sequence:
Synthetic peptide located within the following region: SAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSI
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
SMARCD3; HDAC6; SUMO1; NCOR2; ESR1; RRM2; GPS2; RXRG; GAPDH; RXRA; EP300; SIRT1; SRC; NCOA6; CARM1; HIST1H4A; HIST1H3A; PRMT1; NCOR1; XRCC5; PRKDC; XRCC6; NCOA1; CASP8; SMARCD1;
Blocking Peptide:
For anti-NR1H4 (ARP45626_P050) antibody is Catalog # AAP45626 (Previous Catalog # AAPP11909)
Datasheets/Manuals:
Printable datasheet for anti-NR1H4 (ARP45626_P050) antibody
Target Reference:
Kaeding,J., (2008) Biochem. J. 410 (2), 245-253
Publications:

Yamada, T. et al. Guggulsterone suppresses bile acid-induced and constitutive caudal-related homeobox 2 expression in gut-derived adenocarcinoma cells. Anticancer Res. 30, 1953-60 (2010). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat 20651339

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