NR1H3 Recombinant Protein (OPCD05071)

Catalog No: OPCD05071

NR1H3 Recombinant Protein (OPCD05071) using SDS-PAGE

NR1H3 Recombinant Protein (OPCD05071) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Asn95-Lys434
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 90%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: NR1H3
• Gene Full Name: nuclear receptor subfamily 1 group H member 3
• Alias Symbols: liver X nuclear receptor alpha variant 1;Liver X receptor alpha;LXR-a;LXRA;Nuclear receptor subfamily 1 group H member 3;oxysterols receptor LXR-alpha;RLD-1.
• NCBI Gene Id: 10062
• Protein Name: Oxysterols receptor LXR-alpha
• Description of Target: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (By similarity). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).
• Uniprot ID: Q13133
• Protein Accession #: NP_001123573.1
• Nucleotide Accession #: NM_001130101.2
• Protein Size (# AA): Asn95~Lys434
• Molecular Weight: 41kDa