- Gene Symbol:
- Official Gene Full Name:
- Oxysterols receptor LXR-alpha
- NCBI Gene Id:
- Protein Name:
- Oxysterols receptor LXR-alpha
- Swissprot Id:
- Replacement Item:
- This antibody may replace item sc-1000 from Santa Cruz Biotechnology.
- Immunogen affinity purified.
- Tissue Tool:
- Find tissues and cell lines supported by DNA array analysis to express Nr1h3.
- RNA Seq:
- Find tissues and cell lines supported by RNA-seq analysis to express Nr1h3.
- A synthetic peptide corresponding to a sequence at the C-terminal of human LXRα, identical to the related rat and mouse sequence.
- Predicted Species Reactivity:
- Human, Mouse, Rat
- Predicted Homology Based on Immunogen Sequence:
- Human; Mouse; Rat
- Product Format:
- Reconstitution and Storage:
- 0.2ml of distilled water will yield a concentration of 500ug/ml. At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time. void repeated freezing and thawing.
- Printable datasheet for anti-Nr1h3 (OABB00255) antibody
- Rabbit IgG
- Additional Information:
- Content: 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, .05mg Thimerosal, 0.05mg NaN3
- Background: LXRA is a tissue-specific cofactor that permits RXRA to function as a potent 9cRA receptor with a distinct target gene specificity.1 It specifically interacts with RXRA in vivo to form a functional heterodimer in which RXRA is the ligand-binding subunit. Additionally, LXR activity is critical for physiologic lipid metabolism and transport.2 LXRs are endogenous inhibitors of atherogenesis and are targets for therapeutic intervention in cardiovascular disease. Furthermore, LXRs and their ligands are negative regulators of macrophage inflammatory gene expression.3 LXR is also found that as a transcriptional switch that integrates hepatic glucose metabolism and fatty acid synthesis.4 The LXR-IDOL-LDLR axis defines a complementary pathway to sterol response element-binding proteins for sterol regulation of cholesterol uptake.5
- Target Reference:
- 1) Willy, P. J.; Umesono, K.; Ong, E. S.; Evans, R. M.; Heyman, R. A.; Mangelsdorf, D. J. : LXR, a
nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 9: 1033-1045, 1995. 2) Tangirala, R. K.; Bischoff, E. D.; Joseph, S. B.; Wagner, B. L.; Walczak, R.; Laffitte, B. A.; Daige, C.
L.; Thomas, D.; Heyman, R. A.; Mangelsdorf, D. J.; Wang, X.; Lusis, A. J.; Tontonoz, P.; Schulman,
I. G. : Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc. Nat. Acad. Sci. 99: 11896-11901, 2002. 3) Joseph, S. B.; Castrillo, A.; Laffitte, B. A.; Mangelsdorf, D. J.; Tontonoz, P. : Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nature Med. 9: 213-219, 2003. 4) Mitro, N.; Mak, P. A.; Vargas, L.; Godio, C.; Hampton, E.; Molteni, V.; Kreusch, A.; Saez, E. : The nuclear receptor LXR is a glucose sensor. Nature 445: 219-223, 2007. 5) Zelcer, N.; Hong, C.; Boyadjian, R.; Tontonoz, P. : LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science 325: 100-104, 2009.
Fu, Y. et al. ABCA12 Regulates ABCA1-Dependent Cholesterol Efflux from Macrophages and the Development of Atherosclerosis. Cell Metab. 18, 225-38 (2013). WB, Human, Mouse, Rat 23931754
- Tips Information: