NR1H2 Recombinant Protein (OPCD00379)

Catalog No: OPCD00379

NR1H2 Recombinant Protein (OPCD00379) using SDS-PAGE

NR1H2 Recombinant Protein (OPCD00379) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Met1-Glu446
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 90%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Nr1h2
• Gene Full Name: nuclear receptor subfamily 1, group H, member 2
• Alias Symbols: AI194859;liver X receptor beta;LX;LXR;LXR beta;LXRB;LXRbeta;LXRBSV;NER1;Nuclear receptor subfamily 1 group H member 2;OR-1;oxysterols receptor LXR-beta;retinoid X receptor-interacting protein No.15;RI;RIP15;Ubiquitously-expressed nuclear receptor;ubiquitously-expressed nuclear receptor 2;Un;Unr;Unr2;UR.
• NCBI Gene Id: 22260
• Protein Name: Oxysterols receptor LXR-beta
• Description of Target: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:18055760, PubMed:19520913, PubMed:20427281). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4) (PubMed:18055760, PubMed:19520913, PubMed:20427281). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8 (PubMed:18055760, PubMed:19520913, PubMed:20427281). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (PubMed:18055760, PubMed:19520913, PubMed:20427281). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity).
• Uniprot ID: Q60644
• Protein Accession #: NP_001272446.1
• Nucleotide Accession #: NM_001285517.1
• Protein Size (# AA): Met1~Glu446
• Molecular Weight: 50kDa