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NR1H2 antibody - middle region (ARP33481_P050)

100 ul
$289.00
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Conjugation Options

ARP33481_P050-FITC Conjugated

ARP33481_P050-HRP Conjugated

ARP33481_P050-Biotin Conjugated

Gene Symbol:
NR1H2
NCBI Gene Id:
7376
Official Gene Full Name:
Nuclear receptor subfamily 1, group H, member 2
Protein Name:
Oxysterols receptor LXR-beta
Swissprot Id:
P55055
Protein Accession #:
NP_009052
Nucleotide Accession #:
NM_007121
Alias Symbols:
LXR-b, LXRB, NER, NER-I, RIP15, UNR
Replacement Item:
This antibody may replace item sc-1000 from Santa Cruz Biotechnology.
Description of Target:
NR1H2 is an orphan receptor. NR1H2 binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4).The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995 [PubMed 7625741]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Size (# AA):
461
Molecular Weight:
51kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express NR1H2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express NR1H2.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human NR1H2
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Complete computational species homology data:
Anti-NR1H2 (ARP33481_P050)
Peptide Sequence:
Synthetic peptide located within the following region: ETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYAL
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
RXRG; MDFI; KDM1A; SUV39H1; ACVRL1; LAMC3; NCOR2; YY1; NPY; CDKN1A; PPARGC1B; PDCD4; PIAS1; USP7; PRKCA; SENP3; CORO2A; MPP1; COL4A5; CHD3; RMI1; CSAD; DUSP12; C14orf1; FAF1; SPRY2; HMGXB4; SORBS2; BAG6; VIM; UBE2D1; SMPD1; ROBO2; NCOR1; NRIP1; NCOA3; VDR
Blocking Peptide:
For anti-NR1H2 (ARP33481_P050) antibody is Catalog # AAP33481 (Previous Catalog # AAPP04531)
Datasheets/Manuals:
Printable datasheet for anti-NR1H2 (ARP33481_P050) antibody
Target Reference:
Schmuth,M., (2008) J. Lipid Res. 49 (3), 499-509
Publications:

Fu, Y. et al. ABCA12 Regulates ABCA1-Dependent Cholesterol Efflux from Macrophages and the Development of Atherosclerosis. Cell Metab. 18, 225-38 (2013). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat 23931754

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