NPM1 Antibody - N-terminal region : FITC (ARP34094_T100-FITC)

Catalog No: ARP34094_T100-FITC

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: FITC: Fluorescein Isothiocyanate
• Application: IHC, WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NPM1
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 100%; Guinea Pig: 77%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: DMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKD
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-NPM1 (ARP34094_T100-FITC) antibody is Catalog # AAP34094 (Previous Catalog # AAPP05303)
• Sample Type Confirmation:

  There is BioGPS gene expression data showing that NPM1 is expressed in HepG2

• Reference: Falini,B., et al., (2005) N. Engl. J. Med. 352 (3), 254-266
• Publications:

  Komorek, J. et al. Adenovirus type 5 E1A and E6 proteins of low-risk cutaneous beta-human papillomaviruses suppress cell transformation through interaction with FOXK1/K2 transcription factors. J. Virol. 84, 2719-31 (2010). WB, IHC, IP, Human, Rabbit, Dog, Pig, Horse, Rat, Mouse, Bovine, Guinea pig 20053746

  Lin, S., Coutinho-Mansfield, G., Wang, D., Pandit, S. & Fu, X.-D. The splicing factor SC35 has an active role in transcriptional elongation. Nat. Struct. Mol. Biol. 15, 819-26 (2008). ICC/IF, Human, Rabbit, Dog, Pig, Horse, Rat, Mouse, Bovine, Guinea pig 18641664

Target Info

• Gene Symbol: NPM1
• Gene Full Name: Nucleophosmin (nucleolar phosphoprotein B23, numatrin)
• Alias Symbols: B23, NPM
• NCBI Gene Id: 4869
• Protein Name: Nucleophosmin
• Description of Target: NPM1 is a member of Nucleophosmin (NPM) family. NPM is a ubiquitously expressed nucleolar phosphoprotein that continuously shuttles between the nucleus and cytoplasm
• Uniprot ID: P06748
• Protein Accession #: NP_002511
• Nucleotide Accession #: NM_002520
• Protein Size (# AA): 294
• Molecular Weight: 33kDa
• Protein Interactions: COX8A; NPM2; HUWE1; UBC; PA2G4; FUS; TP53; AURKA; SUMO2; SUMO3; ELF4; STAU1; CDKN2A; LGR4; SUMO1; MDM2; RPA3; RPA2; RPA1; ERG; rev; TRMT61A; OSBP; KPNA1; LIMCH1; ARMCX3; YWHAQ; PARK2; TARDBP; TUBA1C; TAB2; CEP152; DZIP1; COPG1; STK38; COPE; PARK7; AKAP11;