NOTCH4 Antibody (Cleaved-Val1432) (OASG05123)

Catalog No: OASG05123

Size:100 uL

Western Blot using A549, 3T3, SH-SY5Y, K562, HeLa, Mouse Brain

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, ELISA
  Cellular Localization: Cell membrane; Single-pass type I membrane protein.; Notch 4 intracellular domain: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.
  Tissue Specificity: Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.
• Reconstitution and Storage: Store at -20°C for up to 1 year from date of receipt. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the C-terminal region of human Notch 4. Location: 1370-1450aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography.
• Concentration: 1 mg/ml
• Specificity: Cleaved-Notch 4 (V1432) Polyclonal Antibody detects endogenous levels of fragment of activated Notch 4 protein resulting from cleavage adjacent to V1432.
• Application Info: WB: 1:500~2000
  ELISA: 1:5000
• Publications:

  Notch1 signaling determines the plasticity and function of fibroblasts in diabetic wounds. Life Sci Alliance. 3, NULL (2020). 33109684

• Description:
  View product citations for NOTCH4 Antibody (Cleaved-Val1432) (OASG05123) on CiteAb

Target Info

• Gene Symbol: NOTCH4
• Gene Full Name: notch 4
• Alias Symbols: INT3
• NCBI Gene Id: 4855;
• Description of Target: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).
• Uniprot ID: Q99466
• Molecular Weight: 59 kDa