NOTCH3 Recombinant Protein (OPCD05747)

Catalog No: OPCD05747

NOTCH3 Recombinant Protein (OPCD05747) using SDS-PAGE

NOTCH3 Recombinant Protein (OPCD05747) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Leu2053-Gln2318
  Subcellular Location: Cell membrane; Single-pass type I membrane protei
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: NOTCH3
• Gene Full Name: notch receptor 3
• Alias Symbols: CADASIL;CADASIL1;CASIL;IMF2;LMNS;neurogenic locus notch homolog protein 3;notch 3;Notch homolog 3.
• NCBI Gene Id: 4854
• Protein Name: Neurogenic locus notch homolog protein 3
• Description of Target: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).
• Uniprot ID: Q9UM47
• Protein Accession #: NP_000426.2
• Nucleotide Accession #: NM_000435.2
• Protein Size (# AA): Leu2053~Gln2318
• Molecular Weight: 48kDa