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NOTCH2 Antibody (OASA08044)

50ul
$385.00
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Gene Symbol:
NOTCH2
NCBI Gene Id:
4853
Protein Name:
Neurogenic locus notch homolog protein 2
Swissprot Id:
Q04721
Protein Accession #:
NP_077719.2
Alias Symbols:
hN2, AGS2, NOTCH2
Replacement Item:
This antibody may replace item sc-32344 from Santa Cruz Biotechnology.
Description of Target:
RABBIT ANTI HUMAN NOTCH 2
Protein Size (# AA):
2471
Host:
Rabbit
Clonality:
Polyclonal
Application:
ELISA, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express NOTCH2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express NOTCH2.
Immunogen:
The immunogen for anti-NOTCH2 antibody: synthetic peptide corresponding to amino acids 2396-2409 of human Notch 2.
Predicted Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Human
Product Format:
Serum - liquid
Reconstitution and Storage:
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Datasheets/Manuals:
Printable datasheet for anti-NOTCH2 antibody - OASA08044
Specificity:
NOTCH 2
Isotype:
Polyclonal IgG
Application Info:
ELISA:    1/30000 - 1/90000
Western Blotting:    1/400 - 1/2000
:::
Preservative Stabilisers: 0.09% - Sodium Azide (NaN3)
Antiserum Preparation: Antisera to Notch 2 were raised by repeated immunisations of rabbits with highly purified antigen.
:::
Buffer Solutions: Phosphate buffered saline pH7.2
Target Reference:
1. McDaniell, R. et al. (2006) NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway. Am. J. Hum. Genet. 79: 169-173.
2. Witt, C.M. et al. (2003) Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1 B cells. Mol. Cell. Biol. 23: 8637-8650.
3. Saito, T. et al. (2003) Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity. 18: 675-685.
4. Hubmann, R. et al. (2002) Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia. Blood. 99: 3742-3747.
5. Shimizu, K. et al. (2002) Functional diversity among Notch1, Notch2, and Notch3 receptors. Biochem. Biophys. Res. Commun. 291: 775-779.

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