NOTCH2 Antibody (OACD06057)

Catalog No: OACD06057

Product Info

• Predicted Species Reactivity: Human|Porcine|Rat
• Product Format: Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunohistochemistry|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: 2°C to 8°C|-20°C
• Immunogen: Recombinant NOTCH2 (Ala2251 - Asn2466) expressed in E.coli
• Purification: Affinity Purified; Protein A Purified
• Concentration: 0.5 mg/ml
• Specificity: The antibody is a rabbit polyclonal antibody raised against NOTCH2. It has been selected for its ability to recognize NOTCH2 in immunohistochemical staining and western blotting.
• Application Info: WB: 0.5 - 2 ug/mL
  IHC: 5-20 ug/mL
  ICC: 5-20 ug/mL
  Optimal dilutions should be determined by the end user.

Target Info

• Gene Symbol: NOTCH2
• Gene Full Name: notch receptor 2
• Alias Symbols: AGS2;HJCYS;hN2;neurogenic locus notch homolog protein 2;notch 2;Notch homolog 2.
• NCBI Gene Id: 4853
• Protein Name: Neurogenic locus notch homolog protein 2
• Description of Target: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737).
• Uniprot ID: Q04721
• Protein Accession #: NP_001186930.1
• Nucleotide Accession #: NM_001200001