NOTCH2 Antibody - middle region : Biotin (ARP32723_P050-Biotin)

Catalog No: ARP32723_P050-Biotin

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Biotin
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NOTCH2
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 93%
• Peptide Sequence: Synthetic peptide located within the following region: FPASVGKYPTPPSQHSYASSNAAERTPSHSGHLQGEHPYLTPSPESPDQW
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-NOTCH2 (ARP32723_P050-Biotin) antibody is Catalog # AAP32723 (Previous Catalog # AAPP03737)
• Sample Type Confirmation:

  There is BioGPS gene expression data showing that NOTCH2 is expressed in 721_B

• Reference: Troen,G., (er) Haematologica (2008) In press
• Publications:

  Tilley, A. E. et al. Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 179, 457-66 (2009). IHC, Bovine, Dog, Pig, Mouse, Human, Rabbit, Rat, Guinea pig 19106307

Target Info

• Gene Symbol: NOTCH2
• Gene Full Name: Notch 2
• Alias Symbols: hN2, AGS2, HJCYS
• NCBI Gene Id: 4853
• Protein Name: Neurogenic locus notch homolog protein 2
• Description of Target: NOTCH2 is a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. NOTCH2 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. NOTCH2 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: Q04721
• Protein Accession #: NP_077719
• Nucleotide Accession #: NM_024408
• Protein Size (# AA): 2471
• Molecular Weight: 85kDa
• Protein Interactions: ASB14; EGFL7; LATS2; ANKRD28; UBC; SMAD1; NOTCH1; SIN3A; SPEN; SEC24C; TJP1; PSMB1; PLAUR; PCMT1; NDUFV2; NDUFV1; MYOC; CRKL; MAML3; MAML2; CNTN1; DLL1; MAML1; GSK3B; DTX1; MFNG; LFNG; JAG2; JAG1; PSEN2; RBPJ; PSEN1; tat;