NOTCH2 Antibody - C-terminal region (OAGA01645)

Catalog No: OAGA01645

Size:100 ul

Sample (30 ug of whole cell lysate)
A: Hela
5% SDS PAGE
OAGA01645 diluted at 1:1000

Sample (30 ug of whole cell lysate)
A:NIH-3T3 5% SDS PAGE
OAGA01645 diluted at 1:1000

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid. 1XPBS, 40% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, CHIP
• Reconstitution and Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human NOTCH2. The exact sequence is proprietary.
• Purification: Purified by antigen-affinity chromatography.
• Concentration: 1mg/ml
• Application Info: Suggested starting dilutions are as follows: WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Target Info

• Gene Symbol: NOTCH2
• Gene Full Name: notch 2
• Alias Symbols: hN2, AGS2, HJCYS
• NCBI Gene Id: 4853
• Description of Target: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.
• Uniprot ID: Q04721