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Catalog No: OAEE01084
Size:100UG
Price: $259.00
SKU
OAEE01084
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NOTCH1 Antibody (OAEE01084)

Datasheets/ManualsPrintable datasheet for NOTCH1 Antibody (OAEE01084) (OAEE01084)
Product Info
Predicted Species ReactivityHuman|Mouse
Product FormatStabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
ClonalityMonoclonal
ClonemN1A
IsotypeIgG1
HostMouse
ConjugationR-PE
ApplicationFlow cytometry
Reconstitution and Storage2°C to 8°C
ImmunogenGST fusion protein containing cdc10-NCR region of mouse Notch1
PurificationPurified by size-exclusion chromatography
Concentration0.1 mg/ml
SpecificityThe mouse monoclonal antibody mN1A recognizes intracellular domain of Notch 1 protein, mainly its activated form. The unprocessed Notch 1 protein is recognized with lower affinity.
FormulationPE
Storage BufferPhosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
ReferenceSun H, Li L, Vercherat C, Gulbagci NT, Acharjee S, Li J, Chung TK, Thin TH, Taneja R: Stra13 regulates satellite cell activation by antagonizing Notch signaling. J Cell Biol. 2007 May 21;177(4):647-57.
Khwaja SS, Liu H, Tong C, Jin F, Pear WS, van Deursen J, Bram RJ: HIV-1 Rev-binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in mice. J Clin Invest. 2010 Jul 1;120(7):2537-48., Espinosa L, Santos S, Inglés-Esteve J, Muñoz-Canoves P, Bigas A: p65-NFkappaB synergizes with Notch to activate transcription by triggering cytoplasmic translocation of the nuclear receptor corepressor N-CoR. J Cell Sci. 2002 Mar 15;115(Pt 6):1295-303.
Kefas B, Comeau L, Floyd DH, Seleverstov O, Godlewski J, Schmittgen T, Jiang J, diPierro CG, Li Y, Chiocca EA, Lee J, Fine H, Abounader R, Lawler S, Purow B: The neuronal microRNA miR-326 acts in a feedback loop with notch and hastherapeutic potential against brain tumors. J Neurosci. 2009 Dec 2;29(48):15161-8.
Watanabe K, Nagaoka T, Lee JM, Bianco C, Gonzales M, Castro NP, Rangel MC, Sakamoto K, Sun Y, Callahan R, Salomon DS: Enhancement of Notch receptor maturation and signaling sensitivity by Cripto-1. J Cell Biol. 2009 Nov 2;187(3):343-53.
Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M: Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1. Mol Cell Biol. 2008 Jan;28(1):165-76.
Huppert SS, Le A, Schroeter EH, Mumm JS, Saxena MT, Milner LA, Kopan R: Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature. 2000 Jun 22;405(6789):966-70.
And many other.
Gene SymbolNOTCH1
Gene Full Namenotch receptor 1
Alias SymbolsAOS5;AOVD1;hN1;neurogenic locus notch homolog protein 1;notch 1;Notch homolog 1, translocation-associated;TAN1;translocation-associated notch protein TAN-1.
NCBI Gene Id4851
Protein NameNeurogenic locus notch homolog protein 1
Description of TargetFunctions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
Uniprot IDP46531
Protein Accession #NP_060087.3
Nucleotide Accession #NM_017617.3
  1. What is the species homology for "NOTCH1 Antibody (OAEE01084)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse".

  2. How long will it take to receive "NOTCH1 Antibody (OAEE01084)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "NOTCH1 Antibody (OAEE01084)" provided in?

    This item is provided in "Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "NOTCH1 Antibody (OAEE01084)"?

    This target may also be called "AOS5;AOVD1;hN1;neurogenic locus notch homolog protein 1;notch 1;Notch homolog 1, translocation-associated;TAN1;translocation-associated notch protein TAN-1." in publications.

  5. What is the shipping cost for "NOTCH1 Antibody (OAEE01084)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "NOTCH1 Antibody (OAEE01084)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "NOTCH1 Antibody (OAEE01084)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "NOTCH1 Antibody (OAEE01084)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "NOTCH1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "NOTCH1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "NOTCH1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "NOTCH1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "NOTCH1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "NOTCH1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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