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Catalog No: OERA00060
Size:50UG
Price: $169.00
SKU
OERA00060
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NOTCH 1 (Cleaved N terminal) CONTROL PEPTIDE (OERA00060)

Datasheets/ManualsPrintable datasheet for NOTCH 1 (Cleaved N terminal) CONTROL PEPTIDE (OERA00060)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatLiquid (sterile filtered)
ConjugationUnconjugated
ApplicationDot blot
Reconstitution and Storage2°C to 8°C|-20°C
Concentration1 mg/ml
Gene SymbolNOTCH1
Gene Full Namenotch receptor 1
Alias SymbolsAOS5;AOVD1;hN1;neurogenic locus notch homolog protein 1;notch 1;Notch homolog 1, translocation-associated;TAN1;translocation-associated notch protein TAN-1.
NCBI Gene Id4851
Protein NameNeurogenic locus notch homolog protein 1
Description of TargetFunctions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
Uniprot IDP46531
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